Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | CCR1 | P32246 | 2/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7834650 | 0.86 | HDAC1 (0.71) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL7835269 | 0.83 | HDAC1 (0.46) | HDAC1HDAC8CCR1ALDH1A1CYP2D6 | |
| SCHEMBL7832215 | 0.81 | HDAC1 (0.49) | HDAC1HDAC8CCR1HDAC3HDAC4 | |
| SCHEMBL7832515 | 0.81 | HDAC1 (0.51) | HDAC1HDAC8CCR1HDAC3HDAC4 | |
| SCHEMBL7832763 | 0.79 | HDAC1 (0.49) | HDAC1HDAC8CCR1HDAC3HDAC4 | |
| SCHEMBL3416075 | 0.78 | HDAC1 (0.53) | HDAC1HDAC8CYP1A2EPHX1TBXAS1 | |
| SCHEMBL7820426 | 0.76 | CYP2C19 (0.44) | CYP1A2TBXAS1ALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL27587296 | 0.76 | HDAC1 (0.50) | HDAC1HDAC8CYP1A2EPHX1TBXAS1 | |
| SCHEMBL28938718 | 0.75 | PDPK1 (0.52) | ALDH1A1MAPTPDPK1 | |
| SCHEMBL14917995 | 0.75 | TBXAS1 (0.40) | CYP1A2CCR1EPHX1TBXAS1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0737671-B1 | Aromatic hydroxamic acid compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-12-12 | — | — | EP | disclosed |
| US-5804601-A | USEFUL FOR TREATING ALZHEIMER'S DISEASE, MULTIPLE SCLEROSIS, BACTERIAL OR VIRAL MENINGITIS, DOWN'S SYNDROME AND PARKINSON'S DISEASE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-09-08 | — | — | US | disclosed |
| EP-0737671-A2 | Aromatic hydroxamic acid compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1996-10-16 | — | — | EP | disclosed |