Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5795829 | 0.96 | KDM4E (0.44) | KDM4EHSD17B10LMNATP53TSHR | |
| SCHEMBL12107839 | 0.91 | KDM4E (0.43) | KDM4EHSD17B10LMNATP53TSHR | |
| SCHEMBL2475676 | 0.86 | KDM4E (0.41) | KDM4EHSD17B10LMNATP53TSHR | |
| SCHEMBL7812626 | 0.85 | KDM4E (0.45) | KDM4EHSD17B10LMNATSHRALDH1A1 | |
| SCHEMBL7832949 | 0.85 | KDM4E (0.42) | KDM4EHSD17B10LMNATP53TSHR | |
| SCHEMBL7830713 | 0.81 | KDM4E (0.52) | KDM4EHSD17B10LMNATSHRALDH1A1 | |
| SCHEMBL6033408 | 0.80 | KDM4E (0.43) | KDM4EHSD17B10LMNATSHRALDH1A1 | |
| SCHEMBL5669846 | 0.79 | NOTUM (0.63) | LMNATSHRALDH1A1HPGDNOTUM | |
| SCHEMBL30211951 | 0.78 | NOTUM (0.57) | KDM4EHSD17B10LMNATP53TSHR | |
| SCHEMBL7832103 | 0.78 | NOTUM (0.57) | KDM4EHSD17B10LMNATP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1114031-A1 | 4-CARBOXYAMINO-2-SUBSTITUTED-1,2,3,4-TETRAHYDROQUINOLINES AS CETP INHIBITORS | Pfizer Products Inc. (US) | 2001-07-11 | — | — | EP | disclosed |
| WO-2000017164-A1 | 4-CARBOXYAMINO-2-SUBSTITUTED-1,2,3,4-TETRAHYDROQUINOLINES AS CETP INHIBITORS | PFIZER PRODUCTS INC. (US) | 2000-03-30 | — | — | WO | disclosed |