Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.40 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30211951 | 1.00 | NOTUM (0.57) | NOTUMKDM4EABHD6LMNAHSD17B10 | |
| SCHEMBL3618013 | 0.86 | NR1H3 (0.51) | NOTUMKDM4EABHD6LMNAHSD17B10 | |
| SCHEMBL6752845 | 0.84 | NOTUM (0.59) | NOTUMKDM4EABHD6LMNAHSD17B10 | |
| SCHEMBL30767099 | 0.84 | NOTUM (0.59) | NOTUMKDM4ELMNAHSD17B10HTR2A | |
| SCHEMBL5696394 | 0.84 | NOTUM (0.59) | NOTUMKDM4ELMNAHSD17B10HTR2A | |
| SCHEMBL26763830 | 0.84 | NOTUM (0.61) | NOTUMKDM4ELMNAHSD17B10HTR2A | |
| SCHEMBL24011079 | 0.82 | NOTUM (0.84) | NOTUMLMNATP53MAPTSMN1; SMN2 | |
| SCHEMBL7669258 | 0.81 | NOTUM (0.57) | NOTUMKDM4EABHD6LMNAHSD17B10 | |
| SCHEMBL7552151 | 0.80 | NOTUM (0.63) | NOTUMKDM4ELMNAHSD17B10HTR2A | |
| SCHEMBL8523193 | 0.79 | NOTUM (0.53) | NOTUMKDM4ELMNAHSD17B10HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1114031-A1 | 4-CARBOXYAMINO-2-SUBSTITUTED-1,2,3,4-TETRAHYDROQUINOLINES AS CETP INHIBITORS | Pfizer Products Inc. (US) | 2001-07-11 | — | — | EP | disclosed |
| WO-2000017164-A1 | 4-CARBOXYAMINO-2-SUBSTITUTED-1,2,3,4-TETRAHYDROQUINOLINES AS CETP INHIBITORS | PFIZER PRODUCTS INC. (US) | 2000-03-30 | — | — | WO | disclosed |