Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HMGB1 | P09429 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | APEX1 | P27695 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10028289 | 0.80 | TSHR (0.47) | ALDH1A1ALOX15KDM4ECA1CA2 | |
| SCHEMBL8015832 | 0.77 | TSHR (0.64) | ALDH1A1TP53KDM4ETDP1L3MBTL1 | |
| SCHEMBL8227137 | 0.77 | CTNNB1 (0.53) | ALDH1A1TP53KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL2818404 | 0.76 | NPC1 (0.54) | ALDH1A1TP53HPGDSMN1; SMN2KMT2A | |
| Phthalic Acid SCHEMBL28415888 | 0.74 | ALDH1A1 (0.93) | ALDH1A1ALOX15AKR1C3KDM4EHMGB1 | |
| Phthalic Acid SCHEMBL198844 | 0.74 | ALDH1A1 (0.93) | ALDH1A1ALOX15AKR1C3KDM4EHMGB1 | |
| SCHEMBL11950516 | 0.73 | ALDH1A1 (0.70) | ALDH1A1ALOX15AKR1C3USP2TP53 | |
| Phthalic Acid SCHEMBL5903044 | 0.73 | ALDH1A1 (0.78) | ALDH1A1ALOX15AKR1C3KDM4EHMGB1 | |
| Phthalic Acid SCHEMBL29285423 | 0.73 | ALDH1A1 (0.78) | ALDH1A1ALOX15AKR1C3KDM4EHMGB1 | |
| Phthalic Acid SCHEMBL10731126 | 0.72 | ALDH1A1 (0.88) | ALDH1A1ALOX15AKR1C3KDM4EHMGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880522-B1 | 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE DERIVATIVES AMPA AND NMDA RECEPTORS ANTAGONISTS, PREPARATION THEREOF, INTERMEDIATES THEREOF AND DRUGS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2001-09-19 | — | — | EP | disclosed |
| EP-0880522-A1 | 5H,10H-IMIDAZO 1,2-a]INDENO 1,2-e]PYRAZINE-4-ONE DERIVATIVES, PREPARATION THEREOF, INTERMEDIATES THEREOF AND DRUGS CONTAINING SAME | Aventis Pharma S.A. (FR) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997025328-A1 | 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE DERIVATIVES, PREPARATION THEREOF, INTERMEDIATES THEREOF AND DRUGS CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1997-07-17 | — | — | WO | disclosed |