Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 11/20 | 0.38 |
| ▸ | FNTB | P49356 | 11/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | PGGT1B | P53609 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | NRAS | P01111 | 1/20 | 0.34 |
| ▸ | HRAS | P01112 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7805191 | 0.76 | FNTA (0.39) | FNTAFNTBMAPK1PGGT1BKCNH2 | |
| SCHEMBL3684995 | 0.74 | FNTA (0.56) | FNTAFNTBPGGT1BNRASHRAS | |
| SCHEMBL3685883 | 0.74 | FNTA (0.56) | FNTAFNTBPGGT1BNRASHRAS | |
| SCHEMBL3501299 | 0.74 | FNTA (0.56) | FNTAFNTBPGGT1BNRASHRAS | |
| Hydrochloric Acid SCHEMBL9082057 | 0.73 | FNTA (0.55) | FNTAFNTBPGGT1BNRASHRAS | |
| SCHEMBL7845880 | 0.72 | FNTA (0.49) | FNTAFNTBPGGT1BNRASHRAS | |
| SCHEMBL7836006 | 0.71 | FNTA (0.53) | FNTAFNTBPGGT1BKCNH2NRAS | |
| Hydrochloric Acid SCHEMBL7840097 | 0.71 | FNTA (0.48) | FNTAFNTBPGGT1BNRASHRAS | |
| Hydrochloric Acid SCHEMBL7812762 | 0.71 | FNTA (0.47) | FNTAFNTBPGGT1BKCNH2NRAS | |
| Hydrochloric Acid SCHEMBL7838781 | 0.71 | FNTA (0.52) | FNTAFNTBPGGT1BKCNH2NRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891353-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-08 | — | — | EP | claimed |
| EP-0891353-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | claimed |
| WO-1997036892-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | claimed |