Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.75 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.75 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.75 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.75 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.75 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.75 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.75 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.75 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.75 |
| ▸ | TACR1 | P25103 | 3/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.63 |
| ▸ | TNF | P01375 | 1/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.57 |
| ▸ | TACR2 | P21452 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4287307 | 1.00 | HDAC1 (0.75) | HDAC1HDAC8HDAC6HDAC4HDAC7 | |
| SCHEMBL874098 | 0.81 | OPRK1 (0.65) | HDAC1HDAC8HDAC6HDAC4HDAC7 | |
| SCHEMBL7468758 | 0.81 | OPRK1 (0.65) | HDAC1HDAC8HDAC6HDAC4HDAC7 | |
| SCHEMBL874099 | 0.81 | OPRK1 (0.65) | HDAC1HDAC8HDAC6HDAC4HDAC7 | |
| SCHEMBL9026182 | 0.81 | KMT2A (0.58) | HDAC1HDAC8HDAC6HDAC4HDAC7 | |
| SCHEMBL8452072 | 0.81 | HDAC6 (0.73) | HDAC1HDAC8HDAC6HDAC4HDAC7 | |
| SCHEMBL877776 | 0.81 | HDAC6 (0.73) | HDAC1HDAC8HDAC6HDAC4HDAC7 | |
| SCHEMBL876552 | 0.81 | HDAC6 (0.73) | HDAC1HDAC8HDAC6HDAC4HDAC7 | |
| SCHEMBL28359843 | 0.81 | HDAC1 (0.59) | HDAC1HDAC8HDAC6HDAC4HDAC7 | |
| SCHEMBL9026317 | 0.81 | HDAC1 (0.59) | HDAC1HDAC8HDAC6HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0655442-B1 | Piperazine derivatives as Tachykinin antagonists | FUJISAWA PHARMACEUTICAL CO (JP) | 2001-05-23 | — | — | EP | disclosed |
| US-5883098-A | USED AS TACHYKININ ANTAGONISTS IN THE TREATMENT OF RESPIRATORY DISEASES, OPHTHALMIC DISEASES AND INFLAMMATORY DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-03-16 | — | — | US | disclosed |
| US-5670505-A | TACHYKIKIN ANTAGONIST FOR RESPIRATORY DISEASES, OPHTHALMIC DISEASES AND ANTIINFLAMMATORY AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-23 | — | — | US | disclosed |
| EP-0655442-A1 | Piperazine derivatives as Tachykinin antagonists | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-05-31 | — | — | EP | disclosed |