Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 20/20 | 0.56 |
| ▸ | ITGAV | P06756 | 20/20 | 0.56 |
| ▸ | ITGB6 | P18564 | 15/20 | 0.56 |
| ▸ | ITGB1 | P05556 | 8/20 | 0.56 |
| ▸ | ITGB5 | P18084 | 8/20 | 0.56 |
| ▸ | ITGA5 | P08648 | 7/20 | 0.56 |
| ▸ | ITGB8 | P26012 | 7/20 | 0.56 |
| ▸ | ITGA8 | P53708 | 7/20 | 0.56 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6778283 | 0.89 | ITGB3 (0.64) | ITGB3ITGAVITGB6ITGB1ITGB5 | |
| SCHEMBL7370731 | 0.89 | ITGB3 (0.66) | ITGB3ITGAVITGB6ITGB1ITGB5 | |
| SCHEMBL16918474 | 0.87 | ITGB3 (0.61) | ITGB3ITGAVITGB6ITGB1ITGB5 | |
| SCHEMBL7823026 | 0.85 | ITGB3 (0.52) | ITGB3ITGAVITGB6ITGB1ITGB5 | |
| SCHEMBL7832721 | 0.84 | ITGB3 (0.65) | ITGB3ITGAVITGB6ITGB1ITGB5 | |
| SCHEMBL7838264 | 0.81 | ITGB3 (0.51) | ITGB3ITGAVITGB6ITGB1ITGB5 | |
| SCHEMBL19090894 | 0.80 | ITGB3 (0.82) | ITGB3ITGAVITGB6ITGB1ITGB5 | |
| SCHEMBL19090892 | 0.80 | ITGB3 (0.82) | ITGB3ITGAVITGB6ITGB1ITGB5 | |
| SCHEMBL6782048 | 0.79 | ITGB3 (0.53) | ITGB3ITGAVITGB6ITGB1ITGB5 | |
| SCHEMBL16918574 | 0.79 | ITGB3 (0.66) | ITGB3ITGAVITGB6ITGB1ITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | disclosed |
| US-6028223-A | AN INTEGRIN ANTAGONISTS TREATING BONE DISORDER, PERIODONTAL DISEASE, OSTEOPOROSIS, HUMORAL HYPERCALCEMIA OF MALIGNANCY, PAGET'S DISEASE, TUMOR ANGIOGENESIS, DIABETIC RETINOPATHY, ARTHRITIS, SMOOTH MUSCLE CELL MIGRATION AND RESTENOSIS | G. D. SEARLE & CO. (US) | 2000-02-22 | — | — | US | disclosed |