Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 6/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22744042 | 0.85 | PIK3CG (0.56) | NOS1PIK3CGPIK3CAPIK3CBHDAC6 | |
| SCHEMBL8813951 | 0.84 | PIK3CG (0.72) | NOS1PIK3CGPIK3CAPIK3CBHDAC6 | |
| SCHEMBL22716224 | 0.83 | PIK3CG (0.54) | NOS1PIK3CGPIK3CAPIK3CBHDAC6 | |
| SCHEMBL29472120 | 0.83 | PIK3CG (0.54) | NOS1PIK3CGPIK3CAPIK3CBHDAC6 | |
| SCHEMBL22715257 | 0.82 | PIK3CG (0.53) | NOS1PIK3CGPIK3CAPIK3CBHDAC6 | |
| SCHEMBL29439676 | 0.82 | PIK3CG (0.53) | NOS1PIK3CGPIK3CAPIK3CBHDAC6 | |
| SCHEMBL5461542 | 0.81 | NOS1 (0.50) | NOS1PIK3CGPIK3CAPIK3CBHDAC6 | |
| SCHEMBL22744582 | 0.80 | PIK3CG (0.51) | NOS1PIK3CGPIK3CAPIK3CBHDAC6 | |
| SCHEMBL15059842 | 0.79 | PIK3CG (0.76) | NOS1PIK3CGPIK3CAPIK3CBHDAC6 | |
| SCHEMBL3799709 | 0.78 | PIK3CG (0.62) | NOS1PIK3CGPIK3CAPIK3CBHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115710-A1 | PROCESS FOR PREPARING REGIOSPECIFIC SUBSTITUTED PYRAZINE ISOMERS | ABBOTT LABORATORIES (US) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000010983-A1 | PROCESS FOR PREPARING REGIOSPECIFIC SUBSTITUTED PYRAZINE ISOMERS | ABBOTT LABORATORIES (US) | 2000-03-02 | — | — | WO | disclosed |