Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA3 | P32297 | 4/20 | 0.54 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.54 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7818196 | 1.00 | CHRNA3 (0.54) | CHRNA3CHRNB4CHRNB2CHRNA4IRAK4 | |
| SCHEMBL7825997 | 0.91 | KDM4E (0.48) | CHRNB2CHRNA4 | |
| SCHEMBL7827941 | 0.91 | KDM4E (0.48) | CHRNB2CHRNA4 | |
| SCHEMBL7827194 | 0.86 | CHRNA3 (0.54) | CHRNA3CHRNB4CHRNB2CHRNA4IRAK4 | |
| SCHEMBL7817793 | 0.86 | CHRNA3 (0.54) | CHRNA3CHRNB4CHRNB2CHRNA4IRAK4 | |
| SCHEMBL7823526 | 0.86 | CHRNA3 (0.55) | CHRNA3CHRNB4CHRNB2CHRNA4IRAK4 | |
| SCHEMBL7817209 | 0.86 | CHRNA3 (0.55) | CHRNA3CHRNB4CHRNB2CHRNA4IRAK4 | |
| SCHEMBL7817425 | 0.81 | CHRNA3 (0.56) | CHRNA3CHRNB4CHRNB2CHRNA4 | |
| SCHEMBL7817994 | 0.81 | CHRNA3 (0.56) | CHRNA3CHRNB4CHRNB2CHRNA4 | |
| SCHEMBL7460096 | 0.79 | CHRNA3 (0.57) | CHRNA3CHRNB4CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0846114-B1 | 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LAB (US) | 2001-12-05 | — | — | EP | claimed |
| EP-0846114-B1 | 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LAB (US) | 2001-12-05 | — | — | EP | disclosed |