SCHEMBL7824399

SCHEMBL7824399

CCOC(=O)Oc1cn(C2CC2)c2cc(N3CCN(CC)CC3)c(F)cc2c1=O

nearest known ligand 0.70

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.70
ALDH1A1 P00352 6/20 0.70
HPGD P15428 4/20 0.70
HSD17B10 Q99714 4/20 0.70
LMNA P02545 2/20 0.70
MAPT P10636 1/20 0.70
CYP1A2 P05177 1/20 0.51
TOP2A P11388 1/20 0.51
CYP2C9 P11712 1/20 0.51
TOP2B Q02880 1/20 0.51
HRH3 Q9Y5N1 1/20 0.47
PIK3CG P48736 2/20 0.47
PIK3CD O00329 1/20 0.47
PIK3R1 P27986 1/20 0.47
PIK3CA P42336 1/20 0.47
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10913983 0.93 KDM4E (0.73) KDM4EALDH1A1HPGDHSD17B10LMNA
SCHEMBL1851503 0.90 KDM4E (0.77) KDM4EALDH1A1HPGDHSD17B10LMNA
SCHEMBL28709209 0.89 KDM4E (0.73) KDM4EALDH1A1HPGDHSD17B10LMNA
Iodide SCHEMBL10502028 0.89 KDM4E (0.76) KDM4EALDH1A1HPGDHSD17B10LMNA
SCHEMBL29475791 0.87 KDM4E (0.79) KDM4EALDH1A1HPGDHSD17B10LMNA
SCHEMBL8038539 0.87 KDM4E (0.79) KDM4EALDH1A1HPGDHSD17B10LMNA
SCHEMBL7824025 0.85 KDM4E (0.48) KDM4EALDH1A1HPGDHSD17B10LMNA
SCHEMBL10886610 0.85 KDM4E (0.62) KDM4EALDH1A1HPGDHSD17B10LMNA
SCHEMBL10922729 0.84 ALDH1A1 (0.61) KDM4EALDH1A1HPGDHSD17B10LMNA
SCHEMBL10883724 0.84 KDM4E (0.60) KDM4EALDH1A1HPGDHSD17B10LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0828715-B1 N-OXIDES AS ANTIBACTERIAL AGENTS BAYER AG (DE) 2001-08-16 EP disclosed
EP-0205029-A2 Quinolinecarboxylic acids with an antibacterial activity BAYER AG (DE) 1986-12-17 EP disclosed