SCHEMBL7824929

SCHEMBL7824929

Cc1oc2c(NC(=O)c3c(Cl)cccc3Cl)cccc2c1CC(=O)NC1CCCC1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.46
SMN1; SMN2 Q16637 2/20 0.45
TSHR P16473 2/20 0.45
RAB9A P51151 3/20 0.44
MEN1 O00255 1/20 0.44
POLB P06746 2/20 0.42
NPC1 O15118 2/20 0.41
CCNT1 O60563 2/20 0.41
CDK9 P50750 2/20 0.41
CDK5 Q00535 2/20 0.41
CDK5R1 Q15078 2/20 0.41
ALDH1A1 P00352 3/20 0.40
KDM4E B2RXH2 1/20 0.40
HPGD P15428 1/20 0.40
HSD17B10 Q99714 1/20 0.40
TAS1R3 Q7RTX0 1/20 0.40
TAS1R1 Q7RTX1 1/20 0.40
TAS1R2 Q8TE23 1/20 0.40
EPHX2 P34913 1/20 0.39
CASK O14936 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7831834 0.84 SMN1; SMN2 (0.42) KMT2ASMN1; SMN2TSHRRAB9AMEN1
SCHEMBL7831438 0.83 AKR1B1 (0.42) KMT2ASMN1; SMN2RAB9AMEN1POLB
SCHEMBL7824810 0.82 SMN1; SMN2 (0.41) KMT2ASMN1; SMN2RAB9AMEN1ALDH1A1
SCHEMBL7815783 0.81 MEN1 (0.44) KMT2ASMN1; SMN2RAB9AMEN1POLB
SCHEMBL7827815 0.81 MEN1 (0.44) KMT2ASMN1; SMN2RAB9AMEN1POLB
SCHEMBL7828350 0.81 TP53 (0.41) KMT2ASMN1; SMN2TSHRMEN1ALDH1A1
SCHEMBL7828330 0.81 KMT2A (0.43) KMT2ASMN1; SMN2TSHRRAB9AMEN1
SCHEMBL7816495 0.80 HPGD (0.41) KMT2ASMN1; SMN2TSHRMEN1POLB
SCHEMBL7823417 0.80 MEN1 (0.43) KMT2ASMN1; SMN2RAB9AMEN1POLB
SCHEMBL7826786 0.79 CYP2C19 (0.54) SMN1; SMN2TSHRRAB9ANPC1CCNT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0757682-B1 BENZOFURAN DERIVATIVES USEFUL AS INHIBITORS OF BONE RESORPTION FUJISAWA PHARMACEUTICAL CO (JP) 2001-06-20 EP disclosed
US-5858995-A ADMINISTERING TO HUMANS AND ANIMALS IN THE TREATMENT OF DISEASES CAUSED BY ABNORMAL BONE METABOLISM FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-01-12 US disclosed
WO-1995029907-A1 BENZOFURAN DERIVATIVES USEFUL AS INHIBITORS OF BONE RESORPTION FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1995-11-09 WO disclosed