SCHEMBL7816495

SCHEMBL7816495

COCCNC(=O)Cc1c(C)oc2c(NC(=O)c3c(Cl)cccc3Cl)cccc12

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.41
GLA P06280 2/20 0.41
TSHR P16473 1/20 0.41
CA2 P00918 1/20 0.40
P2RX7 Q99572 2/20 0.40
KDM4E B2RXH2 2/20 0.39
GHSR Q92847 1/20 0.38
MEN1 O00255 6/20 0.38
KMT2A Q03164 6/20 0.38
POLB P06746 1/20 0.38
SMN1; SMN2 Q16637 2/20 0.37
CRHBP P24387 1/20 0.37
HTT P42858 1/20 0.37
CRHR2 Q13324 1/20 0.37
L3MBTL1 Q9Y468 2/20 0.37
MAPT P10636 1/20 0.36
PTGS2 P35354 2/20 0.36
MAPK1 P28482 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7824810 0.90 SMN1; SMN2 (0.41) P2RX7KDM4EGHSRMEN1KMT2A
SCHEMBL8345228 0.84 PTGES (0.43) GHSRMEN1KMT2APOLBSMN1; SMN2
SCHEMBL7831438 0.83 AKR1B1 (0.42) GHSRMEN1KMT2APOLBSMN1; SMN2
SCHEMBL7828330 0.83 KMT2A (0.43) HPGDTSHRKDM4EGHSRMEN1
SCHEMBL7815783 0.81 MEN1 (0.44) GHSRMEN1KMT2APOLBSMN1; SMN2
SCHEMBL7827815 0.81 MEN1 (0.44) GHSRMEN1KMT2APOLBSMN1; SMN2
SCHEMBL7824929 0.80 KMT2A (0.46) HPGDTSHRKDM4EMEN1KMT2A
SCHEMBL7823417 0.80 MEN1 (0.43) GHSRMEN1KMT2APOLBSMN1; SMN2
Hydrochloric Acid SCHEMBL7831807 0.80 POLB (0.53) HPGDTSHRP2RX7KDM4EMEN1
SCHEMBL7816944 0.80 KMT2A (0.42) GHSRMEN1KMT2APOLBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0757682-B1 BENZOFURAN DERIVATIVES USEFUL AS INHIBITORS OF BONE RESORPTION FUJISAWA PHARMACEUTICAL CO (JP) 2001-06-20 EP disclosed
US-5962710-A Method of preparing salicyloylamino acids EMISPHERE TECHNOLOGIES, INC. (US) 1999-10-05 US disclosed
WO-1998050341-A1 METHOD OF PREPARING SALICYLOYLAMINO ACIDS EMISPHERE TECHNOLOGIES, INC. (US) 1998-11-12 WO disclosed
EP-0757682-A1 BENZOFURAN DERIVATIVES USEFUL AS INHIBITORS OF BONE RESORPTION FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-02-12 EP disclosed
WO-1995029907-A1 BENZOFURAN DERIVATIVES USEFUL AS INHIBITORS OF BONE RESORPTION FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1995-11-09 WO disclosed