Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 8/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7833816 | 0.70 | CRHR1 (0.37) | CRHR1 | |
| SCHEMBL7833843 | 0.70 | CRHR1 (0.35) | CRHR1 | |
| SCHEMBL20697905 | 0.68 | MAPT (0.36) | CRHR1TLR8POLB | |
| SCHEMBL17178230 | 0.64 | CYP1A2 (0.48) | — | |
| SCHEMBL17178249 | 0.64 | NPC1 (0.51) | CRHR1TLR8POLB | |
| SCHEMBL6082788 | 0.64 | CRHR1 (0.39) | CRHR1TLR8 | |
| SCHEMBL15698778 | 0.64 | POLB (0.51) | CRHR1POLB | |
| SCHEMBL5107615 | 0.64 | POLB (0.45) | CRHR1POLB | |
| SCHEMBL12326180 | 0.63 | CA1 (0.50) | — | |
| SCHEMBL27212614 | 0.63 | POLB (0.47) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090005-A1 | PYRAZOLO 1,5-a]TRIAZINE CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | Du Pont Pharmaceuticals Company (US) | 2001-04-11 | — | — | EP | claimed |
| WO-1999067247-A1 | PYRAZOLO[1,5-a]TRIAZINE CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | DU PONT PHARMACEUTICALS COMPANY (US) | 1999-12-29 | — | — | WO | claimed |
| EP-1090005-A1 | PYRAZOLO 1,5-a]TRIAZINE CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | Du Pont Pharmaceuticals Company (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-1999067247-A1 | PYRAZOLO[1,5-a]TRIAZINE CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | DU PONT PHARMACEUTICALS COMPANY (US) | 1999-12-29 | — | — | WO | disclosed |