Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7221428 | 0.79 | EPHX2 (0.53) | F2RL1ADRB2ADRB1CYP4F2CYP4A11 | |
| SCHEMBL6413567 | 0.79 | NPC1 (0.51) | CA1CA2BCHEACHELMNA | |
| SCHEMBL12548774 | 0.79 | HTT (0.60) | F2RL1ADRB2ADRB1CYP4F2CYP4A11 | |
| SCHEMBL22922181 | 0.78 | CYP4F2 (0.59) | F2RL1ADRB2ADRB1CYP4F2CYP4A11 | |
| SCHEMBL5026807 | 0.78 | CA2 (0.70) | CA1CA2BCHEACHEALDH1A1 | |
| Hydrochloric Acid SCHEMBL21494481 | 0.77 | HTT (0.59) | F2RL1ADRB2ADRB1CYP4F2CYP4A11 | |
| SCHEMBL5179183 | 0.77 | CA2 (0.54) | CA1CA2BCHEACHEKMT2A | |
| SCHEMBL906952 | 0.77 | CA2 (0.57) | CA1CA2BCHEACHEKMT2A | |
| SCHEMBL1445627 | 0.76 | F2RL1 (0.73) | F2RL1LMNAALDH1A1MAPTHTT | |
| SCHEMBL11587096 | 0.75 | CA1 (0.51) | CA1CA2BCHEACHEKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1064289-A1 | HETEROCYCLIC SIGNAL TRANSDUCTION INHIBITORS, COMPOSITIONS CONTAINING THEM | ARIAD PHARMACEUTICALS, INC. (US) | 2001-01-03 | — | — | EP | disclosed |
| WO-1999047529-A1 | HETEROCYCLIC SIGNAL TRANSDUCTION INHIBITORS, COMPOSITIONS CONTAINING THEM | ARIAD PHARMACEUTICALS, INC. (US) | 1999-09-23 | — | — | WO | disclosed |