SCHEMBL7825831

SCHEMBL7825831

CC(C)(CNc1ccnc2cc(Cl)ccc12)NCc1ccccc1O

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 7/20 0.59
CYP2D6 P10635 6/20 0.59
CYP2C8 P10632 5/20 0.59
CYP2C19 P33261 5/20 0.59
KCNH2 Q12809 5/20 0.59
PKM P14618 1/20 0.54
CYP2C9 P11712 3/20 0.52
CYP3A4 P08684 2/20 0.52
CCR1 P32246 1/20 0.49
FERMT2 Q96AC1 2/20 0.47
ABCB11 O95342 1/20 0.47
APP P05067 1/20 0.47
CHRM2 P08172 1/20 0.47
HTR1A P08908 1/20 0.47
CHRM1 P11229 1/20 0.47
DRD2 P14416 1/20 0.47
ADRA2C P18825 1/20 0.47
SLC6A2 P23975 1/20 0.47
PTGS2 P35354 1/20 0.47
OPRM1 P35372 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7837803 0.86 PKM (0.55) CYP1A2CYP2D6CYP2C8CYP2C19KCNH2
Hydrochloric Acid SCHEMBL7836977 0.86 PKM (0.52) CYP1A2CYP2D6CYP2C8CYP2C19KCNH2
SCHEMBL4280268 0.85 CYP1A2 (0.52) CYP1A2CYP2D6CYP2C8CYP2C19KCNH2
Hydrochloric Acid SCHEMBL7839963 0.85 KDM4E (0.55) CYP1A2CYP2D6CYP2C8CYP2C19KCNH2
SCHEMBL4288006 0.85 PKM (0.72) CYP1A2CYP2D6CYP2C8CYP2C19KCNH2
SCHEMBL7835711 0.85 CYP1A2 (0.55) CYP1A2CYP2D6CYP2C8CYP2C19KCNH2
SCHEMBL29578425 0.85 PKM (0.72) CYP1A2CYP2D6CYP2C8CYP2C19KCNH2
Hydrochloric Acid SCHEMBL7835329 0.84 CYP1A2 (0.50) CYP1A2CYP2D6CYP2C8CYP2C19KCNH2
Hydrochloric Acid SCHEMBL7837727 0.84 CYP2D6 (0.52) CYP1A2CYP2D6CYP2C8CYP2C19KCNH2
SCHEMBL4278268 0.84 CYP1A2 (0.49) CYP1A2CYP2D6CYP2C8CYP2C19KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0876346-B1 ANTIMALARIAL QUINOLIN DERIVATIVES HOFFMANN LA ROCHE (CH) 2001-07-25 EP disclosed