Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7835342 | 0.95 | MAPT (0.50) | MAPTKDM4EALDH1A1CYP1A2CA12 | |
| Bicarbonate SCHEMBL8082241 | 0.94 | MAPT (0.57) | MAPTKDM4EALDH1A1CYP1A2CA12 | |
| Acetic Acid SCHEMBL6535946 | 0.91 | MAPT (0.54) | MAPTKDM4EALDH1A1CYP1A2CA12 | |
| Carbamic Acid SCHEMBL28412507 | 0.91 | MAPT (0.54) | MAPTKDM4EALDH1A1CYP1A2CA12 | |
| Benzene SCHEMBL29053622 | 0.90 | MAPT (0.50) | MAPTKDM4EALDH1A1CYP1A2CA12 | |
| Urea SCHEMBL28255233 | 0.89 | MAPT (0.51) | MAPTKDM4EALDH1A1CYP1A2CA12 | |
| SCHEMBL29370549 | 0.88 | MAPT (0.50) | MAPTKDM4EALDH1A1CA12CA1 | |
| SCHEMBL18172 | 0.88 | MAPT (0.50) | MAPTKDM4EALDH1A1CA12CA1 | |
| SCHEMBL27392334 | 0.88 | MAPT (0.50) | MAPTKDM4EALDH1A1CA12CA1 | |
| Malonic Acid SCHEMBL1304383 | 0.88 | MAPT (0.51) | MAPTKDM4EALDH1A1CYP1A2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1204121-C | 1,4-substituted cyclic amine derivatives | EISAI CO LTD (JP) | 2005-06-01 | — | — | CN | disclosed |
| CN-1090631-C | Heterocyclic compound, preparation process thereof and medicinal composition containing same | SEUER LAB (FR) | 2002-09-11 | — | — | CN | disclosed |
| EP-1070054-A1 | AMINE COMPOUNDS, THEIR PRODUCTION AND THEIR USE AS SOMATOSTATIN RECEPTOR ANTAGONISTS OR AGONISTS | Takeda Chemical Industries, Ltd. (JP) | 2001-01-24 | — | — | EP | disclosed |
| CN-1253547-A | 1,4-substituted cyclic amine derivatives | EISAI CO LTD (JP) | 2000-05-17 | — | — | CN | disclosed |
| WO-1999052875-A1 | AMINE COMPOUNDS, THEIR PRODUCTION AND THEIR USE AS SOMATOSTATIN RECEPTOR ANTAGONISTS OR AGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-21 | — | — | WO | disclosed |
| CN-1206712-A | Heterocyclic compound, preparation process thereof and medicinal composition containing same | ADIR (FR) | 1999-02-03 | — | — | CN | disclosed |