Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA3 | P32297 | 4/20 | 0.51 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.48 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7825135 | 1.00 | CHRNA3 (0.51) | CHRNA3CHRNB4CHRNB2CHRNA4CHRNA5 | |
| SCHEMBL7414646 | 0.91 | KDM4E (0.48) | CHRNB2CHRNA4 | |
| SCHEMBL7410574 | 0.91 | KDM4E (0.48) | CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL7413998 | 0.90 | KDM4E (0.47) | CHRNB2CHRNA4 | |
| SCHEMBL7823760 | 0.81 | CHRNA3 (0.59) | CHRNA3CHRNB4CHRNB2CHRNA4CHRNA5 | |
| SCHEMBL7815971 | 0.81 | CHRNA3 (0.59) | CHRNA3CHRNB4CHRNB2CHRNA4CHRNA5 | |
| SCHEMBL7823050 | 0.80 | CHRNA3 (0.55) | CHRNA3CHRNB4CHRNB2CHRNA4 | |
| SCHEMBL7817157 | 0.80 | CHRNA3 (0.55) | CHRNA3CHRNB4CHRNB2CHRNA4 | |
| SCHEMBL7828976 | 0.79 | CHRNA3 (0.56) | CHRNA3CHRNB4CHRNB2CHRNA4CHRNA5 | |
| SCHEMBL7415120 | 0.79 | CHRNA3 (0.56) | CHRNA3CHRNB4CHRNB2CHRNA4CHRNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0846114-B1 | 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LAB (US) | 2001-12-05 | — | — | EP | claimed |
| EP-0846114-B1 | 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LAB (US) | 2001-12-05 | — | — | EP | disclosed |
| EP-0846114-A1 | 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 1998-06-10 | — | — | EP | disclosed |
| WO-1996040682-A1 | 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1996-12-19 | — | — | WO | disclosed |