Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | CCR3 | P51677 | 3/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22397199 | 0.82 | CNR1 (0.44) | CNR1CNR2POLB | |
| SCHEMBL21199085 | 0.82 | CNR1 (0.44) | CNR1CNR2POLB | |
| SCHEMBL7822481 | 0.81 | CCR3 (0.50) | CCR3MAPT | |
| SCHEMBL20015304 | 0.81 | POLB (0.51) | LMNATP53CCR3POLB | |
| SCHEMBL4773466 | 0.80 | TP53 (0.54) | LMNATP53CCR3POLB | |
| SCHEMBL21358915 | 0.76 | CCR3 (0.51) | CCR3POLB | |
| SCHEMBL4149104 | 0.76 | CCR3 (0.51) | CCR3POLB | |
| SCHEMBL23089360 | 0.75 | MEN1 (0.39) | CNR2MAPT | |
| SCHEMBL23090111 | 0.74 | USP2 (0.51) | POLB | |
| SCHEMBL17296109 | 0.73 | NAMPT (0.48) | LMNATP53CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140834-A1 | HETEROCYCLIC PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Du Pont Pharmaceuticals Company (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035877-A1 | HETEROCYCLIC PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-06-22 | — | — | WO | disclosed |