SCHEMBL7826285

SCHEMBL7826285

CN(CCOc1ccc(CC=O)cc1)c1nc2ccccc2o1

nearest known ligand 0.68

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PPARG P37231 19/20 0.68
PPARA Q07869 2/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4744468 0.87 PPARG (0.63) PPARGPPARA
SCHEMBL7826761 0.84 PPARG (0.74) PPARGPPARA
SCHEMBL9005902 0.83 PPARG (0.70) PPARGPPARA
SCHEMBL7825579 0.83 PPARG (0.81) PPARGPPARA
SCHEMBL9085087 0.83 PPARG (0.81) PPARGPPARA
SCHEMBL7976557 0.82 PPARG (0.78) PPARGPPARA
SCHEMBL9086233 0.82 PPARG (0.80) PPARGPPARA
SCHEMBL9005961 0.82 PPARG (0.68) PPARGPPARA
SCHEMBL7826289 0.82 PPARG (0.68) PPARGPPARA
SCHEMBL6802249 0.82 PPARG (0.57) PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648212-B1 BENZOXAZOLE AND BENZOTHIAZOLE DERIVATIVES AS PHARMACEUTICAL SMITHKLINE BEECHAM PLC (GB) 2001-10-24 EP disclosed
EP-1000938-A1 Heterocyclic compounds as pharmaceuticals SMITHKLINE BEECHAM PLC (GB) 2000-05-17 EP disclosed
US-6048883-A HYPOGLYCEMIC AGENT SMITHKLINE BEECHAM P.L.C. (GB) 2000-04-11 US disclosed
EP-0648212-A1 HETEROCYCLIC COMPOUNDS AS PHARMACEUTICAL SMITHKLINE BEECHAM PLC (GB) 1995-04-19 EP disclosed
WO-1994001420-A1 HETEROCYCLIC COMPOUNDS AS PHARMACEUTICAL SMITHKLINE BEECHAM PLC (GB) 1994-01-20 WO disclosed