SCHEMBL7826327

SCHEMBL7826327

Cc1c(C(=O)O)[nH]c2c1CCCC2

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTK2 Q05397 1/20 0.57
HCAR2 Q8TDS4 2/20 0.42
KMT2A Q03164 2/20 0.42
GFER P55789 1/20 0.41
TSHR P16473 4/20 0.41
ALOX15 P16050 2/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
LMNA P02545 1/20 0.39
USP2 O75604 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
HSD17B10 Q99714 2/20 0.37
ALDH1A1 P00352 3/20 0.36
KDM4E B2RXH2 1/20 0.36
HPGD P15428 1/20 0.36
MEN1 O00255 1/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
BRD4 O60885 1/20 0.35
CREBBP Q92793 1/20 0.35
GABRA1 P14867 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8153549 0.96 PTK2 (0.62) PTK2HCAR2KMT2AGFERTSHR
SCHEMBL7823939 0.78 LMNA (0.57) KMT2ATSHRALOX15LMNAL3MBTL1
SCHEMBL8153488 0.74 PTK2 (0.46) PTK2HCAR2KMT2AGFERTSHR
SCHEMBL8144806 0.73 PTK2 (0.45) PTK2HCAR2KMT2AGFERTSHR
SCHEMBL8153552 0.73 PTK2 (0.45) PTK2HCAR2KMT2AGFERTSHR
SCHEMBL2077313 0.73 PTK2 (1.00) PTK2KMT2ATSHRALOX15SMN1; SMN2
SCHEMBL20568603 0.70 KDM4E (0.49) PTK2KMT2AGFERALOX15SMN1; SMN2
SCHEMBL8145079 0.70 PTK2 (0.42) PTK2KMT2ATSHRALOX15SMN1; SMN2
SCHEMBL8157763 0.70 PTK2 (0.42) PTK2KMT2ATSHRALOX15SMN1; SMN2
SCHEMBL12777389 0.70 PTK2 (0.42) PTK2KMT2ATSHRALOX15SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1066257-A2 HETEROCYLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE Sugen, Inc. (US) 2001-01-10 EP disclosed
WO-1999048868-A9 HETEROCYCLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE SUGEN INC (US) 2000-04-20 WO disclosed
WO-1999048868-A2 HETEROCYCLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE SUGEN, INC. (US) 1999-09-30 WO disclosed