Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4190490 | 0.89 | CYP11B2 (0.39) | CYP11B2CYP19A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL4190495 | 0.89 | CYP11B2 (0.39) | CYP11B2CYP19A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL4197083 | 0.88 | CYP11B2 (0.38) | CYP11B2CYP19A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL4197077 | 0.88 | CYP11B2 (0.38) | CYP11B2CYP19A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL7823603 | 0.87 | CYP19A1 (0.36) | CYP11B2CYP19A1LMNASMN1; SMN2GAA | |
| Iodide SCHEMBL4355036 | 0.85 | CYP11B2 (0.36) | CYP11B2CYP19A1MAPTLMNASMN1; SMN2 | |
| Iodide SCHEMBL4355033 | 0.85 | CYP11B2 (0.36) | CYP11B2CYP19A1MAPTLMNASMN1; SMN2 | |
| Iodide SCHEMBL4355027 | 0.85 | CYP11B2 (0.36) | CYP11B2CYP19A1MAPTLMNASMN1; SMN2 | |
| Iodide SCHEMBL4355025 | 0.85 | CYP11B2 (0.36) | CYP11B2CYP19A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL4192151 | 0.84 | CYP11B2 (0.35) | CYP11B2CYP19A1MAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161430-A2 | EPOTHILON DERIVATIVES, METHOD FOR THE PRODUCTION AND THE USE THEREOF AS PHARMACEUTICALS | SCHERING AKTIENGESELLSCHAFT (DE) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000047584-A2 | EPOTHILON DERIVATIVES, METHOD FOR THE PRODUCTION AND THE USE THEREOF AS PHARMACEUTICALS | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-08-17 | — | — | WO | disclosed |