Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | IDE | P14735 | 1/20 | 0.43 |
| ▸ | UBE2N | P61088 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27469280 | 1.00 | KMT2A (0.50) | KMT2AMITFSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL1415727 | 0.86 | SLC6A2 (0.63) | MITFSLC6A4SLC6A2SLC6A3TDP1 | |
| SCHEMBL6936570 | 0.86 | SLC6A2 (0.63) | MITFSLC6A4SLC6A2SLC6A3TDP1 | |
| SCHEMBL27505917 | 0.86 | SLC6A2 (0.63) | MITFSLC6A4SLC6A2SLC6A3TDP1 | |
| SCHEMBL13323425 | 0.80 | SLC6A4 (0.52) | SLC6A4SLC6A2SLC6A3TDP1KCNH2 | |
| SCHEMBL4649567 | 0.79 | SLC6A2 (0.50) | MITFSLC6A4SLC6A2SLC6A3TDP1 | |
| Pyridine SCHEMBL28173600 | 0.79 | SLC6A2 (0.55) | MITFSLC6A4SLC6A2SLC6A3TDP1 | |
| SCHEMBL23058169 | 0.76 | SLC6A2 (0.50) | MITFSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL29247444 | 0.76 | SLC6A2 (0.50) | MITFSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL28861068 | 0.76 | SLC6A2 (0.47) | MITFSLC6A4SLC6A2SLC6A3TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0655442-B1 | Piperazine derivatives as Tachykinin antagonists | FUJISAWA PHARMACEUTICAL CO (JP) | 2001-05-23 | — | — | EP | disclosed |
| US-5883098-A | USED AS TACHYKININ ANTAGONISTS IN THE TREATMENT OF RESPIRATORY DISEASES, OPHTHALMIC DISEASES AND INFLAMMATORY DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-03-16 | — | — | US | disclosed |
| CN-1041923-C | Piperazine derivatives | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-02-03 | — | — | CN | disclosed |
| US-5670505-A | TACHYKIKIN ANTAGONIST FOR RESPIRATORY DISEASES, OPHTHALMIC DISEASES AND ANTIINFLAMMATORY AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-23 | — | — | US | disclosed |
| EP-0655442-A1 | Piperazine derivatives as Tachykinin antagonists | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-05-31 | — | — | EP | disclosed |