SCHEMBL7827638

SCHEMBL7827638

COC(=O)c1cc(-n2cccc2)ccn1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.48
KDM4E B2RXH2 4/20 0.41
MAPT P10636 3/20 0.41
AR P10275 1/20 0.41
ALOX15 P16050 1/20 0.41
TSHR P16473 1/20 0.41
JMJD6 Q6NYC1 1/20 0.40
HTT P42858 1/20 0.40
GABRP O00591 1/20 0.40
GABRD O14764 1/20 0.40
PDE5A O76074 1/20 0.40
LMNA P02545 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
PKM P14618 1/20 0.40
GABRA1 P14867 1/20 0.40
HPGD P15428 1/20 0.40
GABRB1 P18505 1/20 0.40
GABRG2 P18507 1/20 0.40
GABRB3 P28472 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15935035 0.77 ALDH1A1 (0.43) ALDH1A1KDM4EMAPTARJMJD6
SCHEMBL30800091 0.76 ALDH1A1 (0.54) ALDH1A1KDM4EMAPTARALOX15
SCHEMBL15923985 0.76 ALDH1A1 (0.40) ALDH1A1KDM4EARJMJD6MAPK1
SCHEMBL21461103 0.74 MAP3K5 (0.52)
SCHEMBL31704893 0.74 CTSA (0.51) ALDH1A1KDM4EMAPTALOX15PKM
SCHEMBL31704842 0.74 HRH4 (0.52) ALDH1A1KDM4EHTTCYP1A2CYP3A4
SCHEMBL11355924 0.74 HRH4 (0.52) ALDH1A1KDM4EHTTCYP1A2CYP3A4
SCHEMBL3078818 0.73
SCHEMBL850841 0.73 ALDH1A1 (0.51) ALDH1A1KDM4EMAPTARALOX15
SCHEMBL163424 0.73 ALDH1A1 (0.51) ALDH1A1KDM4EMAPTARALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0699185-B1 GUANIDINE DERIVATIVES AS INHIBITORS OF Na+ /H+ EXCHANGE IN CELLS FUJISAWA PHARMACEUTICAL CO (JP) 2001-09-05 EP disclosed
US-5824691-A CARDIOVASCULAR, CEREBROVASCULAR, RENAL DISEASES; SHOCK, ARTERIOSCLEROSIS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-10-20 US disclosed
EP-0784612-A1 UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-07-23 EP disclosed
WO-1996010559-A1 UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-04-11 WO disclosed
EP-0699185-A1 GUANIDINE DERIVATIVES AS INHIBITORS OF Na+ /H+ EXCHANGE IN CELLS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-03-06 EP disclosed
WO-1994026709-A1 GUANIDINE DERIVATIVES AS INHIBITORS OF Na+/H+ EXCHANGE IN CELLS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-11-24 WO disclosed