Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 2/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 4/20 | 0.31 |
| ▸ | MMP9 | P14780 | 4/20 | 0.31 |
| ▸ | ANPEP | P15144 | 2/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | LAP3 | P28838 | 1/20 | 0.31 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.31 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.31 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | MMP7 | P09237 | 2/20 | 0.31 |
| ▸ | MMP1 | P03956 | 2/20 | 0.31 |
| ▸ | MMP14 | P50281 | 2/20 | 0.31 |
| ▸ | MMP10 | P09238 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6946530 | 0.91 | ADAM17 (0.40) | ADAM17TGFBR1APPP2RX3MMP2 | |
| SCHEMBL6946529 | 0.91 | ADAM17 (0.40) | ADAM17TGFBR1APPP2RX3MMP2 | |
| SCHEMBL7957347 | 0.88 | ADAM17 (0.38) | ADAM17TGFBR1APPP2RX3MMP2 | |
| SCHEMBL7957348 | 0.88 | ADAM17 (0.38) | ADAM17TGFBR1APPP2RX3MMP2 | |
| SCHEMBL7845600 | 0.87 | ADAM17 (0.38) | ADAM17TGFBR1APPP2RX3MMP2 | |
| SCHEMBL7957592 | 0.87 | ADAM17 (0.37) | ADAM17TGFBR1APPP2RX3MMP2 | |
| SCHEMBL7840733 | 0.87 | ADAM17 (0.37) | ADAM17TGFBR1APPP2RX3MMP2 | |
| SCHEMBL7840735 | 0.87 | ADAM17 (0.37) | ADAM17TGFBR1APPP2RX3MMP2 | |
| SCHEMBL7957588 | 0.87 | ADAM17 (0.37) | ADAM17TGFBR1APPP2RX3MMP2 | |
| SCHEMBL7955132 | 0.86 | ADAM17 (0.44) | ADAM17TGFBR1APPP2RX3MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137640-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-04 | — | — | EP | disclosed |
| WO-2000035885-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |