Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 13/20 | 0.48 |
| ▸ | ERCC5 | P28715 | 12/20 | 0.48 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.37 |
| ▸ | TYMS | P04818 | 1/20 | 0.34 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7818173 | 0.78 | FEN1 (0.52) | FEN1ERCC5RNASEH1PTPN1TYMS | |
| SCHEMBL7828343 | 0.77 | GSK3B (0.42) | TYMS | |
| SCHEMBL7818129 | 0.77 | ERCC5 (0.55) | FEN1ERCC5RNASEH1PTPN1HAO1 | |
| SCHEMBL7828436 | 0.74 | ERCC5 (0.48) | FEN1ERCC5RNASEH1PTPN1 | |
| SCHEMBL7818280 | 0.69 | ERCC5 (0.52) | FEN1ERCC5RNASEH1PTPN1HAO1 | |
| SCHEMBL11211936 | 0.69 | DAO (0.36) | TYMS | |
| SCHEMBL7829542 | 0.65 | ERCC5 (0.47) | FEN1ERCC5RNASEH1 | |
| SCHEMBL5772644 | 0.63 | ERCC5 (0.44) | FEN1ERCC5RNASEH1 | |
| SCHEMBL7830529 | 0.63 | ERCC5 (0.59) | FEN1ERCC5RNASEH1PTPN1HAO1 | |
| SCHEMBL7828353 | 0.62 | ERCC5 (0.57) | FEN1ERCC5RNASEH1PTPN1HAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086091-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2001-10-10 | — | — | EP | claimed |
| US-6262055-B1 | SULFUR-CONTAINING HETEROARYL DIOXO-BUTYRIC ACID DERIVATIVES | MERCK & CO., INC. | 2001-07-17 | — | — | US | claimed |
| EP-1086091-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (a New Jersey corp.) (US) | 2001-03-28 | — | — | EP | claimed |
| WO-1999062897-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | claimed |
| EP-1086091-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2001-10-10 | — | — | EP | disclosed |
| US-6262055-B1 | SULFUR-CONTAINING HETEROARYL DIOXO-BUTYRIC ACID DERIVATIVES | MERCK & CO., INC. | 2001-07-17 | — | — | US | disclosed |
| EP-1086091-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (a New Jersey corp.) (US) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999062897-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | disclosed |