SCHEMBL7828343

SCHEMBL7828343

C=CCN(CC=C)c1ccc(C(C)=O)s1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 1/20 0.42
LMNA P02545 3/20 0.40
TSHR P16473 1/20 0.40
L3MBTL1 Q9Y468 2/20 0.37
ALDH1A1 P00352 4/20 0.36
MAPT P10636 2/20 0.36
KDM4E B2RXH2 2/20 0.36
GAA P10253 2/20 0.36
GLA P06280 1/20 0.36
PRNP P04156 1/20 0.36
RECQL P46063 1/20 0.36
RXFP1 Q9HBX9 1/20 0.36
TYMS P04818 1/20 0.35
SMN1; SMN2 Q16637 2/20 0.34
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
ERN1 O75460 1/20 0.34
CYP3A4 P08684 1/20 0.33
CYP2A6 P11509 1/20 0.33
CYP2C9 P11712 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7828429 0.77 FEN1 (0.48) TYMS
SCHEMBL7818151 0.76 GSK3B (0.44) GSK3BLMNATSHRL3MBTL1ALDH1A1
SCHEMBL11211936 0.74 DAO (0.36) TYMSNPC1RAB9A
SCHEMBL7832388 0.72 CRHBP (0.44) GSK3BLMNATSHRMAPTSMN1; SMN2
SCHEMBL7818253 0.70 ALDH1A1 (0.41) GSK3BLMNATSHRALDH1A1SMN1; SMN2
SCHEMBL2872059 0.69 GSK3B (0.67) GSK3BLMNATSHRL3MBTL1ALDH1A1
SCHEMBL4564604 0.67 MAPT (0.50) LMNATSHRL3MBTL1ALDH1A1MAPT
SCHEMBL7818275 0.65 HDAC4 (0.45) GSK3BTSHRALDH1A1KDM4ENPC1
SCHEMBL4480592 0.64
SCHEMBL11160378 0.64 F2 (0.58) GSK3BLMNATSHRL3MBTL1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1086091-A4 HIV INTEGRASE INHIBITORS MERCK & CO INC (US) 2001-10-10 EP disclosed
US-6262055-B1 SULFUR-CONTAINING HETEROARYL DIOXO-BUTYRIC ACID DERIVATIVES MERCK & CO., INC. 2001-07-17 US disclosed
EP-1086091-A1 HIV INTEGRASE INHIBITORS Merck & Co., Inc. (a New Jersey corp.) (US) 2001-03-28 EP disclosed
WO-1999062897-A1 HIV INTEGRASE INHIBITORS MERCK & CO., INC. (US) 1999-12-09 WO disclosed