Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 10/20 | 0.43 |
| ▸ | EDNRA | P25101 | 10/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7828049 | 0.93 | EDNRB (0.48) | EDNRBEDNRAALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL7815810 | 0.92 | EDNRB (0.52) | EDNRBEDNRAALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL7824960 | 0.89 | EDNRB (0.52) | EDNRBEDNRAALDH1A1L3MBTL1HTT | |
| SCHEMBL7823695 | 0.89 | EDNRB (0.43) | EDNRBEDNRAALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL7069871 | 0.89 | EDNRB (0.46) | EDNRBEDNRAALDH1A1L3MBTL1POLB | |
| SCHEMBL7817828 | 0.86 | ALDH1A1 (0.47) | EDNRBEDNRAALDH1A1L3MBTL1POLB | |
| SCHEMBL7828200 | 0.86 | ALDH1A1 (0.47) | EDNRBEDNRAALDH1A1L3MBTL1POLB | |
| SCHEMBL7817363 | 0.85 | EDNRA (0.46) | EDNRBEDNRAALDH1A1L3MBTL1POLB | |
| SCHEMBL7829746 | 0.84 | EDNRB (0.54) | EDNRBEDNRAALDH1A1L3MBTL1POLB | |
| SCHEMBL7828613 | 0.84 | EDNRB (0.52) | EDNRBEDNRAALDH1A1TDP1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | claimed |