Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.45 |
| ▸ | FEN1 | P39748 | 7/20 | 0.43 |
| ▸ | ERCC5 | P28715 | 6/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7828681 | 0.85 | FEN1 (0.51) | MAPK8PTPN1FEN1ERCC5RAB9A | |
| SCHEMBL7832900 | 0.84 | ERCC5 (0.44) | MAPK8PTPN1FEN1ERCC5 | |
| SCHEMBL4676178 | 0.80 | MAPK8 (0.44) | MAPK8FEN1MAPK1RAB9AHCAR2 | |
| SCHEMBL4676180 | 0.80 | MAPK8 (0.44) | MAPK8FEN1MAPK1RAB9AHCAR2 | |
| SCHEMBL6943572 | 0.76 | PTPN1 (0.69) | PTPN1FEN1ERCC5HCAR2MAPT | |
| SCHEMBL7826756 | 0.75 | PTPN1 (0.51) | PTPN1FEN1ERCC5MAPK1RAB9A | |
| SCHEMBL7828973 | 0.73 | ERCC5 (0.50) | PTPN1FEN1ERCC5MAPK1RAB9A | |
| SCHEMBL7193837 | 0.71 | HCAR2 (0.48) | PTPN1FEN1ERCC5RAB9AHCAR2 | |
| SCHEMBL4671226 | 0.69 | HCAR2 (0.39) | MAPK8HCAR2MAPTADORA2AADORA2B | |
| SCHEMBL4673398 | 0.69 | HCAR2 (0.39) | MAPK8HCAR2ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086091-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2001-10-10 | — | — | EP | claimed |
| US-6262055-B1 | SULFUR-CONTAINING HETEROARYL DIOXO-BUTYRIC ACID DERIVATIVES | MERCK & CO., INC. | 2001-07-17 | — | — | US | claimed |
| EP-1086091-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (a New Jersey corp.) (US) | 2001-03-28 | — | — | EP | claimed |
| WO-1999062897-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | claimed |
| EP-1086091-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2001-10-10 | — | — | EP | disclosed |
| US-6262055-B1 | SULFUR-CONTAINING HETEROARYL DIOXO-BUTYRIC ACID DERIVATIVES | MERCK & CO., INC. | 2001-07-17 | — | — | US | disclosed |
| EP-1086091-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (a New Jersey corp.) (US) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999062897-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | disclosed |