SCHEMBL7828527

SCHEMBL7828527

CC(C)C[C@@H](C(=O)NN1C(=O)[C@H](C(C)C)NC1=S)[C@H](CCCc1ccccc1)C(=O)NO

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 9/20 0.44
MMP13 P45452 3/20 0.44
ALDH1A1 P00352 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
APP P05067 2/20 0.42
MMP8 P22894 3/20 0.41
MMP2 P08253 9/20 0.38
MMP3 P08254 8/20 0.38
MMP7 P09237 8/20 0.38
TSHR P16473 1/20 0.38
FCER2 P06734 1/20 0.38
ADAM17 P78536 2/20 0.37
MMP9 P14780 2/20 0.37
MMP14 P50281 2/20 0.37
MMP12 P39900 1/20 0.37
MMP10 P09238 1/20 0.37
PSEN1 P49768 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7957370 1.00 MMP1 (0.44) MMP1MMP13ALDH1A1CYP1A2CYP3A4
SCHEMBL7957373 1.00 MMP1 (0.44) MMP1MMP13ALDH1A1CYP1A2CYP3A4
SCHEMBL7838489 0.92 MMP1 (0.46) MMP1MMP13APPMMP8MMP2
SCHEMBL7837906 0.92 MMP1 (0.46) MMP1MMP13APPMMP8MMP2
SCHEMBL7957317 0.92 MMP1 (0.46) MMP1MMP13APPMMP8MMP2
SCHEMBL7838493 0.92 MMP1 (0.46) MMP1MMP13APPMMP8MMP2
SCHEMBL7955056 0.89 GAA (0.45) MMP1MMP13APPMMP8MMP2
SCHEMBL7955050 0.89 GAA (0.45) MMP1MMP13APPMMP8MMP2
SCHEMBL7955052 0.89 GAA (0.45) MMP1MMP13APPMMP8MMP2
SCHEMBL7953732 0.85 MMP1 (0.46) MMP1MMP13APPMMP8MMP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1137640-A1 CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2001-10-04 EP claimed
US-6281363-B1 ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS; AUTOIMMUNE DISORDERS HOFFMANN-LA ROCHE INC. 2001-08-28 US claimed
WO-2000035885-A1 CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2000-06-22 WO claimed
EP-1137640-A1 CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2001-10-04 EP disclosed
US-6281363-B1 ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS; AUTOIMMUNE DISORDERS HOFFMANN-LA ROCHE INC. 2001-08-28 US disclosed
WO-2000035885-A1 CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2000-06-22 WO disclosed