Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 5/20 | 0.36 |
| ▸ | MMP13 | P45452 | 2/20 | 0.36 |
| ▸ | APP | P05067 | 7/20 | 0.35 |
| ▸ | CTSL | P07711 | 5/20 | 0.33 |
| ▸ | CTSK | P43235 | 5/20 | 0.33 |
| ▸ | CTSS | P25774 | 4/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 3/20 | 0.33 |
| ▸ | MMP2 | P08253 | 3/20 | 0.33 |
| ▸ | MMP7 | P09237 | 1/20 | 0.33 |
| ▸ | MMP10 | P09238 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7828836 | 0.94 | MMP1 (0.37) | MMP1MMP13APPCTSLCTSK | |
| SCHEMBL7836672 | 0.91 | MMP1 (0.35) | MMP1MMP13APPMMP9MMP2 | |
| SCHEMBL7837998 | 0.86 | MMP1 (0.37) | MMP1MMP13APPMMP9MMP2 | |
| SCHEMBL7827613 | 0.86 | MMP1 (0.37) | MMP1MMP13APPMMP9MMP2 | |
| SCHEMBL7955118 | 0.85 | MMP1 (0.37) | MMP1MMP13APPMMP9MMP2 | |
| SCHEMBL7840034 | 0.84 | MMP1 (0.36) | MMP1MMP13APPMMP9MMP2 | |
| SCHEMBL7960591 | 0.84 | MMP1 (0.36) | MMP1MMP13APPMMP9MMP2 | |
| SCHEMBL7837761 | 0.83 | MMP1 (0.36) | MMP1MMP13APPMMP9MMP2 | |
| SCHEMBL7835338 | 0.83 | MMP1 (0.37) | MMP1MMP13APPMMP9MMP2 | |
| SCHEMBL7848834 | 0.82 | GAA (0.37) | MMP1MMP13APPMMP9MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137640-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-04 | — | — | EP | disclosed |
| WO-2000035885-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |