Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR8 | P51685 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7848901 | 0.92 | CCR8 (0.48) | CCR8HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL7848895 | 0.92 | CCR8 (0.48) | CCR8HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL7848899 | 0.92 | CCR8 (0.48) | CCR8HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL6221871 | 0.87 | CHRM3 (0.54) | CCR8HTR1AADRA1DADRA1AADRA1B | |
| Trifluoroacetic Acid SCHEMBL7832819 | 0.82 | CCR8 (0.47) | CCR8HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL6969668 | 0.81 | CCR8 (0.55) | CCR8HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL6221266 | 0.81 | CCR8 (0.49) | CCR8HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL6222506 | 0.80 | CCR8 (0.54) | CCR8HTR1AADRA1DADRA1AADRA1B | |
| Oxalic Acid SCHEMBL6223378 | 0.79 | CCR8 (0.47) | CCR8HTR1AADRA1DADRA1AADRA1B | |
| Oxalic Acid SCHEMBL6223377 | 0.79 | CCR8 (0.47) | CCR8HTR1AADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144404-A1 | PIPERIDINYLQUINOLINES AS PROTEIN TYROSINE KINASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000043383-A1 | PIPERIDINYLQUINOLINES AS PROTEIN TYROSINE KINASE INHIBITORS | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-07-27 | — | — | WO | disclosed |