Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR8 | P51685 | 2/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6222506 | 0.88 | CCR8 (0.54) | CCR8KCNH2HTR1AADRA1DADRA1A | |
| SCHEMBL6221871 | 0.88 | CHRM3 (0.54) | CCR8HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL6221266 | 0.82 | CCR8 (0.49) | CCR8HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL6214270 | 0.82 | KCNH2 (0.51) | KCNH2GSK3BDYRK1A | |
| SCHEMBL7828696 | 0.81 | CCR8 (0.50) | CCR8KCNH2HTR1AADRA1DADRA1A | |
| SCHEMBL6224111 | 0.81 | CCR8 (0.49) | CCR8KCNH2HTR1AADRA1DADRA1A | |
| SCHEMBL6224107 | 0.81 | CCR8 (0.49) | CCR8KCNH2HTR1AADRA1DADRA1A | |
| SCHEMBL6224110 | 0.81 | CCR8 (0.49) | CCR8KCNH2HTR1AADRA1DADRA1A | |
| SCHEMBL6970302 | 0.80 | ADRA1A (0.48) | KCNH2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL7848895 | 0.80 | CCR8 (0.48) | CCR8KCNH2HTR1AADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051413-B1 | QUINOLINE DERIVATIVES AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2003-06-04 | — | — | EP | claimed |
| EP-1051413-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-15 | — | — | EP | claimed |
| WO-1999037635-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 1999-07-29 | — | — | WO | claimed |
| EP-1051413-B1 | QUINOLINE DERIVATIVES AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2003-06-04 | — | — | EP | disclosed |