Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7823701 | 0.82 | MEN1 (0.43) | KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL7826676 | 0.82 | POLB (0.57) | KMT2ALMNASMN1; SMN2MEN1 | |
| SCHEMBL7815903 | 0.81 | SMN1; SMN2 (0.49) | KMT2ALMNASMN1; SMN2MEN1 | |
| SCHEMBL7830797 | 0.79 | MAOB (0.52) | KMT2ASMN1; SMN2S1PR4MEN1 | |
| SCHEMBL8341821 | 0.79 | POLB (0.47) | KMT2ALMNASMN1; SMN2S1PR4S1PR5 | |
| SCHEMBL8346730 | 0.78 | POLB (0.49) | KMT2ALMNASMN1; SMN2MEN1AKR1C3 | |
| SCHEMBL5187435 | 0.77 | KMT2A (0.72) | KMT2ALMNASMN1; SMN2KCNK3KCNK9 | |
| SCHEMBL8345366 | 0.77 | POLB (0.45) | KMT2ALMNAMEN1AKR1C3 | |
| SCHEMBL7827806 | 0.77 | S1PR2 (0.46) | KMT2ALMNASMN1; SMN2S1PR4S1PR5 | |
| SCHEMBL7824410 | 0.75 | KCNMA1 (0.62) | KMT2ALMNASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757682-B1 | BENZOFURAN DERIVATIVES USEFUL AS INHIBITORS OF BONE RESORPTION | FUJISAWA PHARMACEUTICAL CO (JP) | 2001-06-20 | — | — | EP | disclosed |
| US-5858995-A | ADMINISTERING TO HUMANS AND ANIMALS IN THE TREATMENT OF DISEASES CAUSED BY ABNORMAL BONE METABOLISM | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-01-12 | — | — | US | disclosed |
| EP-0757682-A1 | BENZOFURAN DERIVATIVES USEFUL AS INHIBITORS OF BONE RESORPTION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-02-12 | — | — | EP | disclosed |
| WO-1995029907-A1 | BENZOFURAN DERIVATIVES USEFUL AS INHIBITORS OF BONE RESORPTION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-11-09 | — | — | WO | disclosed |