Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 16/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL410317 | 0.90 | PDE10A (1.00) | PDE10A | |
| SCHEMBL7856900 | 0.80 | PDE10A (0.81) | PDE10AALDH1A1L3MBTL1KDM4EMEN1 | |
| SCHEMBL14825136 | 0.78 | PDE10A (0.63) | PDE10AALDH1A1L3MBTL1KDM4EMEN1 | |
| SCHEMBL410771 | 0.77 | PDE10A (1.00) | PDE10AMEN1KMT2A | |
| SCHEMBL410839 | 0.77 | PDE10A (1.00) | PDE10AMEN1KMT2A | |
| SCHEMBL410784 | 0.76 | PDE10A (1.00) | PDE10A | |
| SCHEMBL411048 | 0.73 | PDE10A (1.00) | PDE10A | |
| SCHEMBL410783 | 0.73 | PDE10A (0.89) | PDE10A | |
| SCHEMBL410930 | 0.73 | PDE10A (1.00) | PDE10AALDH1A1L3MBTL1KDM4EMEN1 | |
| SCHEMBL7863620 | 0.73 | PDE10A (0.81) | PDE10AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8846000-B2 | Radiolabeled PDE10 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-09-30 | — | — | US | claimed |
| EP-2435048-B1 | RADIOLABELED PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2019-07-03 | — | — | EP | disclosed |
| EP-2435048-B1 | RADIOLABELED PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2019-07-03 | — | — | EP | disclosed |
| WO-2010138585-A1 | PYRIMIDINONES AS PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-12-02 | — | — | WO | disclosed |