Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 14/20 | 0.52 |
| ▸ | PDK2 | Q15119 | 14/20 | 0.52 |
| ▸ | PDK3 | Q15120 | 14/20 | 0.52 |
| ▸ | PDK4 | Q16654 | 14/20 | 0.52 |
| ▸ | ABCC9 | O60706 | 3/20 | 0.47 |
| ▸ | ABCC8 | Q09428 | 3/20 | 0.47 |
| ▸ | KCNJ11 | Q14654 | 3/20 | 0.47 |
| ▸ | KCNJ8 | Q15842 | 3/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7835352 | 0.87 | PDK1 (0.49) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL7833256 | 0.84 | PDK1 (0.46) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL7821294 | 0.83 | PDK1 (0.45) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL7831455 | 0.82 | PDK1 (0.49) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL8796551 | 0.82 | PDK1 (0.47) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL8796630 | 0.77 | PDK1 (0.46) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL10558018 | 0.76 | MAPT (0.56) | NPC1LMNAGAASMN1; SMN2NPSR1 | |
| SCHEMBL7833602 | 0.75 | PDK1 (0.53) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL7830325 | 0.74 | PDK1 (0.50) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL7833552 | 0.74 | PDK1 (0.46) | PDK1PDK2PDK3PDK4ABCC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798288-B1 | TRICICLIC COMPOUNDS | KYOWA HAKKO KOGYO KK (JP) | 2001-05-16 | — | — | EP | disclosed |