Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | SLC10A2 | Q12908 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.44 |
| ▸ | TUBB | P07437 | 1/20 | 0.44 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.44 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.44 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.44 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.44 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.44 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.44 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.44 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.44 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7821607 | 0.93 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPTALDH1A1KDM4ENSD2 | |
| SCHEMBL7834185 | 0.90 | MAPK1 (0.49) | SMN1; SMN2MAPTSLC10A2ALDH1A1KDM4E | |
| SCHEMBL7831401 | 0.90 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPTALDH1A1KDM4ELMNA | |
| SCHEMBL7831847 | 0.90 | SLC10A2 (0.45) | SMN1; SMN2MAPTSLC10A2ALDH1A1KDM4E | |
| SCHEMBL7833295 | 0.90 | SLC10A2 (0.45) | SMN1; SMN2MAPTSLC10A2ALDH1A1TUBB4A | |
| SCHEMBL8734614 | 0.84 | SLC10A2 (0.48) | MAPTSLC10A2ALDH1A1KDM4ETUBB4A | |
| SCHEMBL7829897 | 0.84 | SLC10A2 (0.48) | MAPTSLC10A2ALDH1A1TUBB4ATUBB | |
| SCHEMBL8132332 | 0.83 | SLC10A2 (0.46) | SMN1; SMN2MAPTSLC10A2ALDH1A1KDM4E | |
| SCHEMBL7834113 | 0.82 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPTALDH1A1LMNARAB9A | |
| SCHEMBL7820993 | 0.82 | SLC10A2 (0.47) | SMN1; SMN2MAPTSLC10A2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567107-B1 | Quinoline and quinazoline derivatives for treating arthritis | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-11-21 | — | — | EP | claimed |
| EP-0567107-A1 | Quinoline and quinazoline derivatives for treating arthritis | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-10-27 | — | — | EP | claimed |
| EP-0567107-B1 | Quinoline and quinazoline derivatives for treating arthritis | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-11-21 | — | — | EP | disclosed |
| EP-0567107-A1 | Quinoline and quinazoline derivatives for treating arthritis | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-10-27 | — | — | EP | disclosed |