Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 17/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 14/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 12/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 11/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 9/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.52 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7831425 | 0.99 | HDAC1 (0.54) | HDAC1HDAC2HDAC8HDAC3HDAC4 | |
| SCHEMBL7832547 | 0.87 | TBXAS1 (0.54) | HDAC1HDAC2HDAC8HDAC3HDAC4 | |
| SCHEMBL7831705 | 0.86 | TBXAS1 (0.52) | — | |
| SCHEMBL12046891 | 0.79 | HDAC1 (0.55) | HDAC1HDAC2HDAC8HDAC3HDAC4 | |
| SCHEMBL12046887 | 0.77 | HDAC1 (0.53) | HDAC1HDAC2HDAC8HDAC3HDAC4 | |
| SCHEMBL7832985 | 0.76 | HDAC1 (0.54) | HDAC1HDAC2HDAC8HDAC3HDAC4 | |
| SCHEMBL7833278 | 0.75 | KDM4E (0.54) | HDAC1HDAC2HDAC8HDAC3HDAC4 | |
| SCHEMBL3384637 | 0.74 | HDAC1 (0.69) | HDAC1HDAC2HDAC8HDAC3HDAC4 | |
| SCHEMBL7831767 | 0.74 | HDAC1 (0.76) | HDAC1HDAC2HDAC8HDAC3HDAC4 | |
| SCHEMBL7820996 | 0.74 | HDAC1 (0.76) | HDAC1HDAC2HDAC8HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0737671-B1 | Aromatic hydroxamic acid compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-12-12 | — | — | EP | disclosed |
| US-5804601-A | USEFUL FOR TREATING ALZHEIMER'S DISEASE, MULTIPLE SCLEROSIS, BACTERIAL OR VIRAL MENINGITIS, DOWN'S SYNDROME AND PARKINSON'S DISEASE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-09-08 | — | — | US | disclosed |
| EP-0737671-A2 | Aromatic hydroxamic acid compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1996-10-16 | — | — | EP | disclosed |