Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | TARDBP | Q13148 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | ACHE | P22303 | 1/20 | 0.60 |
| ▸ | APEX1 | P27695 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.60 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12245628 | 1.00 | SIGMAR1 (0.73) | SIGMAR1KMT2AL3MBTL1HSD17B10TARDBP | |
| SCHEMBL7842968 | 0.98 | SIGMAR1 (0.70) | SIGMAR1KMT2AL3MBTL1HSD17B10TARDBP | |
| SCHEMBL7842810 | 0.88 | SIGMAR1 (0.65) | SIGMAR1KMT2AL3MBTL1HSD17B10TARDBP | |
| SCHEMBL2380388 | 0.86 | SIGMAR1 (0.62) | SIGMAR1KMT2AL3MBTL1HSD17B10TARDBP | |
| SCHEMBL12245575 | 0.86 | SIGMAR1 (0.62) | SIGMAR1KMT2AL3MBTL1HSD17B10TARDBP | |
| SCHEMBL12245576 | 0.86 | SIGMAR1 (0.66) | SIGMAR1KMT2AL3MBTL1HSD17B10TARDBP | |
| Hydrochloric Acid SCHEMBL7841651 | 0.86 | SIGMAR1 (0.62) | SIGMAR1KMT2AL3MBTL1HSD17B10TARDBP | |
| SCHEMBL15894790 | 0.86 | SIGMAR1 (0.62) | SIGMAR1KMT2AL3MBTL1HSD17B10TARDBP | |
| SCHEMBL15877963 | 0.86 | SIGMAR1 (0.62) | SIGMAR1KMT2AL3MBTL1HSD17B10TARDBP | |
| SCHEMBL2380386 | 0.86 | SIGMAR1 (0.62) | SIGMAR1KMT2AL3MBTL1HSD17B10TARDBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313164-B1 | TO ENHANCE THE ACTIVITY OF GLUTATHIONE RECLUCTASE; FOR THERAPY AND PROPHYLAXIS OF CARTARACTS | SANKYO COMPANY, LIMITED (JP) | 2001-11-06 | — | — | US | disclosed |
| EP-1070710-A2 | Dithiolan derivatives, their preparation and their therapeutic effect | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |
| US-6013663-A | CATARACT THERAPY OR PREVENTION | SANKYO COMPANY, LIMITED (JP) | 2000-01-11 | — | — | US | disclosed |
| EP-0869126-A1 | Dithiolan derivatives, their preparation and their therapeutic effect | Sankyo Company Limited (JP) | 1998-10-07 | — | — | EP | disclosed |