Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 18/20 | 0.47 |
| ▸ | FNTB | P49356 | 18/20 | 0.47 |
| ▸ | PGGT1B | P53609 | 8/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | NRAS | P01111 | 1/20 | 0.45 |
| ▸ | HRAS | P01112 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7856950 | 0.99 | FNTA (0.47) | FNTAFNTBPGGT1BKCNH2NRAS | |
| SCHEMBL7841098 | 0.85 | FNTA (0.49) | FNTAFNTBPGGT1BNRASHRAS | |
| Hydrochloric Acid SCHEMBL7992200 | 0.85 | FNTA (0.48) | FNTAFNTBPGGT1BNRASHRAS | |
| SCHEMBL7833379 | 0.79 | FNTA (0.62) | FNTAFNTBPGGT1B | |
| SCHEMBL7839464 | 0.78 | FNTA (0.62) | FNTAFNTBPGGT1BKCNH2NRAS | |
| Hydrochloric Acid SCHEMBL7977774 | 0.78 | FNTA (0.61) | FNTAFNTBPGGT1B | |
| Hydrochloric Acid SCHEMBL7844275 | 0.78 | FNTA (0.61) | FNTAFNTBPGGT1BKCNH2NRAS | |
| SCHEMBL11367275 | 0.74 | SIGMAR1 (0.50) | KCNH2 | |
| SCHEMBL7683462 | 0.72 | FNTA (0.61) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL7682385 | 0.71 | FNTA (0.61) | FNTAFNTBPGGT1BCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087770-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-11-14 | — | — | EP | disclosed |
| EP-1087770-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-04 | — | — | EP | disclosed |
| US-6172076-B1 | HETEROCYCLE-SUBSTITUTED 1,3,8-TRIAZASPIRO(4,5)DECANE DERIVATIVES; TREATING ARTERIOSCLEROSIS | MERCK & CO., INC. | 2001-01-09 | — | — | US | disclosed |
| WO-1999065494-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-12-23 | — | — | WO | disclosed |