Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 7/20 | 0.72 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.72 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.72 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.72 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.72 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.72 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.55 |
| ▸ | CNR1 | P21554 | 1/20 | 0.55 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | GABRP | O00591 | 3/20 | 0.48 |
| ▸ | GABRD | O14764 | 3/20 | 0.48 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.48 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.48 |
| ▸ | GABRE | P78334 | 3/20 | 0.48 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2615408 | 0.85 | GABRA1 (0.78) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL2615411 | 0.85 | GABRA1 (0.78) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL5350970 | 0.84 | GABRA1 (0.68) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Ro-052921 SCHEMBL1365706 | 0.84 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Ro-052921 SCHEMBL29979594 | 0.84 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL5356267 | 0.84 | GABRA1 (0.72) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Ro-053061 SCHEMBL2615409 | 0.82 | PDE4D (0.71) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Ro-053061 SCHEMBL2615407 | 0.82 | PDE4D (0.71) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL19481193 | 0.82 | KMT2A (0.56) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL28124939 | 0.82 | GABRA1 (0.68) | GABRA1GABRA5GABRA3GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089977-A1 | COMPOUNDS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS | Elan Pharmaceuticals, Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-1999067219-A1 | COMPOUNDS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS | ELAN PHARMACEUTICALS, INC. (US) | 1999-12-29 | — | — | WO | disclosed |