Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.68 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.42 |
| ▸ | GCGR | P47871 | 4/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6505614 | 0.81 | PTGS2 (0.66) | PTGS2MAPK13GCGRMAPK12MAPK11 | |
| SCHEMBL7832748 | 0.81 | PTGS2 (0.66) | PTGS2MAPK13GCGRMAPK12MAPK11 | |
| SCHEMBL213502 | 0.81 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL6157381 | 0.81 | PTGS2 (0.69) | PTGS2PTGS1MAPTKDM4EMEN1 | |
| SCHEMBL7833299 | 0.81 | PTGS2 (0.47) | PTGS2PTGS1MAPK13GCGRMAPK12 | |
| SCHEMBL7832741 | 0.79 | PTGS2 (0.79) | PTGS2PTGS1 | |
| SCHEMBL27587266 | 0.78 | PTGS2 (0.64) | PTGS2PTGS1MAPTKDM4EMEN1 | |
| SCHEMBL8808319 | 0.77 | PTGS2 (0.47) | PTGS2PTGS1KDM4EALDH1A1MAPK13 | |
| SCHEMBL7845143 | 0.77 | PTGS1 (0.44) | PTGS2PTGS1MEN1KMT2AMAPK13 | |
| SCHEMBL7842639 | 0.77 | PTGS2 (0.69) | PTGS2PTGS1MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |