Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.42 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.42 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3083162 | 0.90 | ACVR2A (0.52) | POLBNPC1RAB9ASMN1; SMN2ACVR2A | |
| SCHEMBL7832129 | 0.89 | PPARG (0.42) | NPC1RAB9ASMN1; SMN2ACVR2ATGFBR2 | |
| SCHEMBL7830755 | 0.88 | TSHR (0.41) | POLBNPC1RAB9ASMN1; SMN2ACVR2A | |
| SCHEMBL7833519 | 0.85 | MAPT (0.34) | POLBRAB9AACVR2ATGFBR2MAPT | |
| SCHEMBL7834007 | 0.80 | NR4A2 (0.44) | ACVR2ATGFBR2PPARAALKBH1ANO1 | |
| SCHEMBL3078380 | 0.80 | ACVR2A (0.50) | NPC1RAB9ASMN1; SMN2ACVR2ATGFBR2 | |
| SCHEMBL3087743 | 0.79 | ACVR2A (0.45) | NPC1RAB9AACVR2ATGFBR2ALDH1A1 | |
| SCHEMBL3084466 | 0.79 | ACVR2A (0.45) | ACVR2ATGFBR2FFAR1ALDH1A1 | |
| SCHEMBL7819943 | 0.79 | KMT2A (0.44) | POLBNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3096993 | 0.79 | ACVR2A (0.58) | NPC1RAB9ASMN1; SMN2ACVR2ATGFBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1084114-A1 | ISOTHIAZOLE DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999062890-A1 | ISOTHIAZOLE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 1999-12-09 | — | — | WO | disclosed |