Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 6/20 | 0.41 |
| ▸ | PPIF | P30405 | 1/20 | 0.39 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.39 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.39 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3086638 | 0.91 | ACVR2A (0.48) | NR4A2MAOBPPIFACVR2ATGFBR2 | |
| SCHEMBL7832129 | 0.88 | PPARG (0.42) | NR4A2ACVR2ATGFBR2ALKBH1 | |
| SCHEMBL7830755 | 0.81 | TSHR (0.41) | NR4A2MAOBACVR2ATGFBR2MRGPRX4 | |
| SCHEMBL7832071 | 0.80 | POLB (0.44) | ACVR2ATGFBR2ANO1PPARAALKBH1 | |
| SCHEMBL3084724 | 0.80 | ACVR2A (0.44) | MAOBACVR2ATGFBR2PARP10 | |
| SCHEMBL3078380 | 0.80 | ACVR2A (0.50) | ACVR2ATGFBR2PARP10 | |
| SCHEMBL3082256 | 0.80 | ACVR2A (0.49) | MAOBACVR2ATGFBR2 | |
| SCHEMBL3078483 | 0.79 | ACVR2A (0.48) | MAOBACVR2ATGFBR2MAOAPARP10 | |
| SCHEMBL3091467 | 0.79 | ACVR2A (0.48) | ACVR2ATGFBR2ANO1 | |
| SCHEMBL3081929 | 0.79 | ACVR2A (0.48) | MAOBACVR2ATGFBR2GRM5MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1084114-A1 | ISOTHIAZOLE DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999062890-A1 | ISOTHIAZOLE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 1999-12-09 | — | — | WO | disclosed |