Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 6/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 7/20 | 0.48 |
| ▸ | NT5E | P21589 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2659465 | 0.86 | FGFR1 (0.69) | FGFR1THRBHPGDKDRALDH1A1 | |
| SCHEMBL7819821 | 0.86 | KDR (0.49) | FGFR1HPGDNT5EKDRALDH1A1 | |
| SCHEMBL2649859 | 0.86 | HPGD (0.47) | FGFR1HPGDNT5EKDRSMN1; SMN2 | |
| SCHEMBL7468883 | 0.84 | NT5E (0.60) | FGFR1HPGDNT5EKDRALDH1A1 | |
| SCHEMBL2648570 | 0.82 | ATM (0.46) | FGFR1HPGDNT5EKDR | |
| SCHEMBL2643064 | 0.81 | KDR (0.45) | FGFR1HPGDNT5EKDRALDH1A1 | |
| SCHEMBL2644846 | 0.81 | KDR (0.45) | FGFR1HPGDNT5EKDRALDH1A1 | |
| SCHEMBL7830383 | 0.81 | KDR (0.45) | FGFR1HPGDNT5EKDRALDH1A1 | |
| SCHEMBL27483316 | 0.80 | FGFR1 (0.41) | FGFR1HPGDNT5EKDR | |
| SCHEMBL2643652 | 0.79 | NT5E (0.44) | FGFR1HPGDNT5EKDRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1164134-A1 | Benzimidazole compounds and their use as modulators of the GABA A receptor complex | NEUROSEARCH A/S (DK) | 2001-12-19 | — | — | EP | disclosed |
| EP-0821684-B1 | BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA A? RECEPTOR COMPLEX | NEUROSEARCH AS (DK) | 2001-12-05 | — | — | EP | disclosed |
| US-5922724-A | Benzimidazole compounds and their use as modulators of the GABA a receptor complex | NEUROSEARCH A/S (DK) | 1999-07-13 | — | — | US | disclosed |