Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | NT5E | P21589 | 2/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 10/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7819821 | 0.90 | KDR (0.49) | KDRNT5EFGFR1ALDH1A1HPGD | |
| SCHEMBL2644846 | 0.85 | KDR (0.45) | KDRNT5EFGFR1ALDH1A1HPGD | |
| SCHEMBL7830383 | 0.85 | KDR (0.45) | KDRNT5EFGFR1ALDH1A1HPGD | |
| SCHEMBL7468883 | 0.85 | NT5E (0.60) | KDRNT5EFGFR1ALDH1A1HPGD | |
| SCHEMBL2643652 | 0.82 | NT5E (0.44) | KDRNT5EFGFR1ALDH1A1HPGD | |
| SCHEMBL2643078 | 0.81 | CYP3A4 (0.49) | KDRNT5EFGFR1HTTALDH1A1 | |
| SCHEMBL7828198 | 0.81 | NT5E (0.43) | KDRNT5EFGFR1HTTALDH1A1 | |
| SCHEMBL7832076 | 0.81 | FGFR1 (0.57) | KDRNT5EFGFR1ALDH1A1HPGD | |
| SCHEMBL2646371 | 0.81 | GABRA1 (0.53) | KDRNT5EFGFR1ALDH1A1 | |
| SCHEMBL2643150 | 0.81 | KDR (0.40) | KDRNT5EFGFR1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1164134-A1 | Benzimidazole compounds and their use as modulators of the GABA A receptor complex | NEUROSEARCH A/S (DK) | 2001-12-19 | — | — | EP | disclosed |
| EP-0821684-B1 | BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA A? RECEPTOR COMPLEX | NEUROSEARCH AS (DK) | 2001-12-05 | — | — | EP | disclosed |
| US-5922724-A | Benzimidazole compounds and their use as modulators of the GABA a receptor complex | NEUROSEARCH A/S (DK) | 1999-07-13 | — | — | US | disclosed |
| EP-0821684-A1 | BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA A? RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996033194-A1 | BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA A RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 1996-10-24 | — | — | WO | disclosed |