Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 9/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7834399 | 0.83 | CYP1A2 (0.49) | CYP1A2CYP3A4CYP2D6CYP2C19LMNA | |
| SCHEMBL7830304 | 0.83 | CYP1A2 (0.39) | CYP1A2CYP3A4CYP2D6CYP2C19LMNA | |
| SCHEMBL7829252 | 0.80 | ABL1 (0.46) | CYP1A2CYP3A4CYP2D6CYP2C19LMNA | |
| SCHEMBL2643607 | 0.70 | HDAC2 (0.39) | CYP1A2CYP3A4CYP2D6CYP2C19LMNA | |
| SCHEMBL7831832 | 0.67 | CYP1A2 (0.45) | CYP1A2CYP3A4CYP2D6CYP2C19LMNA | |
| SCHEMBL2643659 | 0.66 | HDAC2 (0.43) | CYP1A2CYP3A4CYP2D6CYP2C19LMNA | |
| SCHEMBL9071943 | 0.66 | HDAC2 (0.41) | CYP1A2CYP3A4CYP2D6CYP2C19LMNA | |
| SCHEMBL2643656 | 0.66 | HDAC2 (0.41) | CYP1A2CYP3A4CYP2D6CYP2C19LMNA | |
| SCHEMBL2643742 | 0.65 | MAP4K4 (0.42) | CYP1A2CYP3A4CYP2D6CYP2C19LMNA | |
| SCHEMBL2643125 | 0.65 | SYK (0.37) | CYP1A2CYP3A4CYP2D6CYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1164134-A1 | Benzimidazole compounds and their use as modulators of the GABA A receptor complex | NEUROSEARCH A/S (DK) | 2001-12-19 | — | — | EP | disclosed |
| EP-0821684-B1 | BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA A? RECEPTOR COMPLEX | NEUROSEARCH AS (DK) | 2001-12-05 | — | — | EP | disclosed |
| US-5922724-A | Benzimidazole compounds and their use as modulators of the GABA a receptor complex | NEUROSEARCH A/S (DK) | 1999-07-13 | — | — | US | disclosed |