Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP8B1 | Q9UNU6 | 1/20 | 0.63 |
| ▸ | GPBAR1 | Q8TDU6 | 10/20 | 0.59 |
| ▸ | NR1H4 | Q96RI1 | 7/20 | 0.59 |
| ▸ | CDC25A | P30304 | 1/20 | 0.57 |
| ▸ | CDC25B | P30305 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.52 |
| ▸ | SLC10A2 | Q12908 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.52 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.52 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL294537 | 0.86 | GPBAR1 (0.74) | CYP8B1GPBAR1NR1H4CDC25ACDC25B | |
| SCHEMBL11383608 | 0.86 | GPBAR1 (0.74) | CYP8B1GPBAR1NR1H4CDC25ACDC25B | |
| SCHEMBL9224303 | 0.83 | CYP2D6 (0.65) | GPBAR1CDC25ACDC25BCYP2C19CYP2D6 | |
| SCHEMBL28408 | 0.83 | CYP2D6 (0.65) | GPBAR1CDC25ACDC25BCYP2C19CYP2D6 | |
| SCHEMBL3447573 | 0.83 | CYP2D6 (0.65) | GPBAR1CDC25ACDC25BCYP2C19CYP2D6 | |
| SCHEMBL133952 | 0.83 | CYP2D6 (0.65) | GPBAR1CDC25ACDC25BCYP2C19CYP2D6 | |
| SCHEMBL23748470 | 0.83 | GPBAR1 (0.83) | CYP8B1GPBAR1NR1H4CYP2C19MEN1 | |
| SCHEMBL19866259 | 0.83 | GPBAR1 (0.83) | CYP8B1GPBAR1NR1H4CYP2C19MEN1 | |
| SCHEMBL18071923 | 0.83 | GPBAR1 (0.83) | CYP8B1GPBAR1NR1H4CYP2C19MEN1 | |
| SCHEMBL15292877 | 0.83 | GPBAR1 (0.83) | CYP8B1GPBAR1NR1H4CYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0710112-B1 | Use of vitamin D and derivatives thereof for the manufacture of a medicament for protection against neuron loss | UNIV KENTUCKY (US) | 2001-12-05 | — | — | EP | claimed |