Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | TOP2A | P11388 | 2/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7831302 | 0.85 | MEN1 (0.50) | TNFTOP2ACYP4F2CYP4A11CYP3A4 | |
| SCHEMBL7833020 | 0.84 | CYP4F2 (0.41) | TNFTOP2ACYP4F2CYP4A11CYP3A4 | |
| SCHEMBL7832985 | 0.80 | HDAC1 (0.54) | RCE1 | |
| SCHEMBL7829068 | 0.77 | CYP4F2 (0.61) | TNFTOP2ACYP4F2CYP4A11CYP3A4 | |
| SCHEMBL7831168 | 0.77 | CYP1A1 (0.54) | TNFTOP2ACYP4F2CYP4A11CYP3A4 | |
| SCHEMBL711239 | 0.76 | CYP3A4 (0.52) | TOP2ACYP4F2CYP4A11CYP3A4CYP2D6 | |
| SCHEMBL9614852 | 0.76 | CYP4F2 (0.63) | TNFTOP2ACYP4F2CYP4A11CYP3A4 | |
| SCHEMBL7832871 | 0.75 | TNF (0.48) | TNFTOP2ACYP4F2CYP4A11CYP3A4 | |
| SCHEMBL9506941 | 0.75 | TBXA2R (0.51) | CYP4F2CYP4A11CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL28633131 | 0.74 | SMN1; SMN2 (0.51) | TOP2ACYP4F2CYP4A11CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0737671-B1 | Aromatic hydroxamic acid compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-12-12 | — | — | EP | disclosed |
| US-5804601-A | USEFUL FOR TREATING ALZHEIMER'S DISEASE, MULTIPLE SCLEROSIS, BACTERIAL OR VIRAL MENINGITIS, DOWN'S SYNDROME AND PARKINSON'S DISEASE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-09-08 | — | — | US | disclosed |
| EP-0737671-A2 | Aromatic hydroxamic acid compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1996-10-16 | — | — | EP | disclosed |