Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARK7 | Q99497 | 5/20 | 0.67 |
| ▸ | NSD2 | O96028 | 1/20 | 0.60 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | ALDH3A1 | P30838 | 5/20 | 0.52 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11150483 | 0.91 | PARK7 (0.63) | PARK7NSD2CHRM5ALDH1A1ALDH3A1 | |
| SCHEMBL28909405 | 0.90 | PARK7 (0.75) | PARK7NSD2CHRM5ALDH1A1ALDH3A1 | |
| SCHEMBL28547209 | 0.87 | PARK7 (0.71) | PARK7NSD2CHRM5ALDH1A1ALDH3A1 | |
| SCHEMBL28546572 | 0.85 | PARK7 (0.69) | PARK7NSD2CHRM5ALDH1A1ALDH3A1 | |
| SCHEMBL28533459 | 0.85 | PARK7 (0.69) | PARK7NSD2CHRM5ALDH1A1ALDH3A1 | |
| SCHEMBL28539851 | 0.85 | PARK7 (0.69) | PARK7NSD2CHRM5ALDH1A1ALDH3A1 | |
| SCHEMBL28547202 | 0.85 | PARK7 (0.69) | PARK7NSD2CHRM5ALDH1A1ALDH3A1 | |
| SCHEMBL28533382 | 0.83 | PARK7 (0.65) | PARK7NSD2CHRM5ALDH1A1ALDH3A1 | |
| SCHEMBL11149802 | 0.80 | PARK7 (0.62) | PARK7NSD2CHRM5ALDH1A1ALDH3A1 | |
| SCHEMBL20254404 | 0.80 | PARK7 (1.00) | PARK7NSD2CHRM5ALDH1A1ALDH3A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780388-B1 | 5HT1Dalpha and 5HT2A ligands | LILLY CO ELI (GB) | 2001-08-16 | — | — | EP | disclosed |
| US-6166040-A | Indole compounds | ELI LILLY AND COMPANY LIMITED (GB) | 2000-12-26 | — | — | US | disclosed |
| EP-0963983-A1 | Indol-2-ones as serotonin modulators | ELI LILLY AND COMPANY LIMITED (GB) | 1999-12-15 | — | — | EP | disclosed |
| WO-1999058525-A1 | INDOLE DERIVATIVES AS 5-HT2A LIGANDS AND AS SEROTONINE REUPTAKE INHIBITORS | ELI LILLY AND COMPANY LIMITED (GB) | 1999-11-18 | — | — | WO | disclosed |
| US-5773448-A | NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY LIMITED (GB) | 1998-06-30 | — | — | US | disclosed |
| EP-0780388-A1 | 5HT1Dalpha and 5HT2A ligands | LILLY INDUSTRIES LIMITED (GB) | 1997-06-25 | — | — | EP | disclosed |