Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7845047 | 0.92 | PTGS2 (0.66) | PTGS2PTGS1HSD11B1KDM4EALDH1A1 | |
| SCHEMBL7844755 | 0.92 | PTGS2 (0.72) | PTGS2PTGS1HSD11B1KDM4EALDH1A1 | |
| SCHEMBL7840911 | 0.91 | PTGS2 (0.65) | PTGS2PTGS1HSD11B1KDM4EALDH1A1 | |
| SCHEMBL7845071 | 0.91 | PTGS2 (0.65) | PTGS2PTGS1HSD11B1KDM4EALDH1A1 | |
| SCHEMBL7833474 | 0.90 | PTGS2 (0.76) | PTGS2PTGS1 | |
| SCHEMBL7843832 | 0.88 | PTGS2 (0.59) | PTGS2PTGS1HSD11B1KDM4EALDH1A1 | |
| SCHEMBL7842211 | 0.88 | PTGS2 (0.64) | PTGS2PTGS1HSD11B1KDM4EALDH1A1 | |
| SCHEMBL7833462 | 0.86 | PTGS2 (0.87) | PTGS2PTGS1 | |
| SCHEMBL7845070 | 0.86 | PTGS2 (0.87) | PTGS2PTGS1 | |
| SCHEMBL7847356 | 0.85 | PTGS2 (0.58) | PTGS2PTGS1HSD11B1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |